The top network, “DNA Replication, Recombination, and Repair, Gene Expression, Cancer”, formed by genes exhibiting altered expression in MLT-pretreated MCF-7 cells upon MMS exposure relative to untreated MMS-exposed cells. Upregulated transcripts are shaded in red, while downregulated transcripts are shaded in green, with color intensity signifying the magnitude of fold change. Each interaction is supported by at least one literature reference identified in the Ingenuity Pathway Knowledge Base, with solid lines representing direct interactions, and dashed lines representing indirect interactions.
Liu et al. BMC Cell Biology 2013 14:1 doi:10.1186/1471-2121-14-1