Radial positioning of chromosome territories determined via two-dimensional FISH in adult fibroblasts (SOB), embryonic fibroblasts (ESK4), and MSCs during S-phase and in lymphocytes. Erosion analyses were performed by ascertaining the distribution of the mean proportion of hybridisation signal per chromosome (%), normalised by the percentage of DAPI signal, over five concentric shells of equal area from the nuclear periphery to centre . The x-axis displays the shells from 1–5 (left to right), with 1 being the most peripheral shell and 5 being the most internal shell. The y-axis shows signal (%)/ DAPI (%), from 0 to 1.8 with 0.2 increments.
Foster et al. BMC Cell Biology 2012 13:30 doi:10.1186/1471-2121-13-30