Effect of JNK inhibition on NB TGF-β1-induced alterations in lung architecture. NB TGF-β1 TG and WT liter-mate control mice on dox or regular water, with or without treatment with JNKi, were sacrificed at PN10, with activation of TGF-β1 at PN7. H&E staining of lung histology in low (10X; top row) and high (from inset in upper panel; 20X; bottom row) power magnification is shown demonstrating partial rescue of altered alveolar architecture of NB TGF-β1 TG mice lungs with JNKi (5A and 5B). The figures are illustrative of a minimum of 4 animals in each group. Alveolar size, as measured by chord length, confirmed the above observations (5C). Each bar represents the mean ± SEM of a minimum of three animals. NB: newborn; WT: wild type; TGF-β1: transforming growth factor beta1 transgenic; Reg: regular water; Dox: doxcycline water; JNKi: JNK inhibitor. #P ≤ 0.01, ##P ≤ 0.001.
Li et al. BMC Cell Biology 2011 12:54 doi:10.1186/1471-2121-12-54