Interconversion of the phosphoinositides PI(3,4,5)P3 and PI(4,5)P2 by phosphorylation/dephosphorylation at the 3 position of the inositol ring (bold arrow). In cells of D. discoideum both the PI3-kinases and the PI3-phosphatase PTEN shuttle between a cytoplasmic and an activated membrane-bound state. R1 and R2, hydrophobic membrane anchors of the phosphoinositides.
Gerisch et al. BMC Cell Biology 2011 12:42 doi:10.1186/1471-2121-12-42