Figure 8.

Exposure to 3 μM Cdk4 inhibitor caused NMuMG/Fucci2 cells to undergo G₁ arrest or endoreplication in a cell-cycle phase dependent manner. When the drug was applied, the observed cells were in early G₁ (A), late G₁ (B), G₁/S (C), and S/G₂ (D) phases. Scale bar, 10 μm. (B) A white arrow indicates the endoreplication. (C and D) M, M phase. A solid arrow indicates a daughter cell, which was tracked. A solid arrowhead indicates the other daughter cell.