Table 1

Ten first down and upregulated genes at P0 in hypoxia.

Gene

Fold expression

H/N

Genbank

Accession

Putative Function


    Down Regulated

RRM2

5.94

NM_001034

Ribonucleotide Reductase

XRCC2

5.80

CR749256

X Ray damage DNA Repair

KIF24

5.16

AK001795

Kinesin: chromatid assembly

POLQ

4.99

AF090919

DNA polymerase theta

E2F8

4.95

NM_024680

Cell cycle progression

FANCD2

4.93

NM_001018115

DNA Repair

ESCO2

4.86

NM_001017420

Sister chromatid cohesion

AURKB

4.74

NM_004217

Chromosome segregation

CENPN

4.48

AK023669

Binding to Centromeres

MKI67

4.46

NM_002417

Cell proliferation

    Up Regulated

TCF1

6.96

NM_000545

Hepatic Transcription Factor

LEP

6.39

NM_000230

Metabolism, apoptosis, angiogenesis

ANGPT2

5.69

NM_001147

Antagonise vascular remodelling

ZP1

5.47

NM_207341

Sperm binding to zona pellucida

VWF

5.41

NM_000552

Platelet binding to endothelium

GIMAP4

5.37

NM_018326

T-cell development, Tumor suppressor ?

CD93

4.56

NM_012072

Intercellular adhesion, clearance apoptotic cells

PLVAP

4.25

NM_031310

Adhesion of Vascular Endothelial cells ?

ESAM

4.24

NM_138961

Adhesion of Endothelial cells

PCDH17

4.14

NM_001040429

Cell-cell connexions in the brain


Comparative analysis of transcriptome from MSC at P0 in hypoxia versus normoxia. Mean from 3 distinct samples.

Basciano et al. BMC Cell Biology 2011 12:12   doi:10.1186/1471-2121-12-12

Open Data