Table 1

3D telomere characteristics of Hodgkin and Reed-Sternberg cells in U-HO1 and U-HO1-PTPN1

Cell type

Parameter

H-HO1

H-HO1-PTPN1

p-value


Hodgkin

Total nuclear volume

4121 ± 1350 μm3

3330 ± 844 μm3

ns

Telomeres/cell (n)

(Total telomere volume)

53.8 ± 28.0

56.2 ± 19.9

ns

Telomeres/1000 μm3

of nuclear volume (n)

14.0 ± 8.4

17.2 ± 6.1

ns

Telomere aggregates/cell (n)

6.0 ± 4.0

6.8 ± 4.2

ns

Cells with ≥ 20 telomere

aggregates (%)

2.9

2.8

ns

Very short telomeres

(< 5000 units; %)

21.2

18.3

0.0407

Reed-Sternberg

Total nuclear volume

15301 ± 4641 μm3

14839 ± 6722 μm3

ns

Telomeres/cell (n)

(Total telomere volume)

123.0 ± 75.3

105.7 ± 62.7

ns

Telomeres/1000 μm3

of nuclear volume (n)

13.7 ± 30.8

7.8 ± 4.0

ns

Telomere aggregates/cell (n)

13.8 ± 11.7

12.9 ± 10.5

ns

Cells with ≥ 20 telomere

aggregates (%)

17.2

13.8

ns

Very short telomeres

(< 5000 units; %)

23.4

13.8

< 0.0001


ns: p > 0.05

Knecht et al. BMC Cell Biology 2010 11:99   doi:10.1186/1471-2121-11-99

Open Data