Reducing the level of hRev7 in human fibroblast cells renders them more sensitive to the cytotoxic effects of a variety of different types of DNA damaging agents. Cell strains 2.5 and 3.2, which have significantly reduced hRev7 protein, (closed symbols) were compared to their parental strain and the vector control strain (open symbols) for their sensitivity to the cytotoxic effects of (A) the DNA cross-linking agent cisplatin, (B) ionizing radiation (IR), and (C) the alkylating agent N-methyl-N-hydroxyurea (MNU). The lines represent the least squares regression for the data.
Neal et al. BMC Cell Biology 2010 11:97 doi:10.1186/1471-2121-11-97