Table 1

Chaperone level in MLE-12 cells expressing mutant SP-CI73T in response to drugs used in ILD therapy.

HSP 90

Calreticulin

HSP 70

Calnexin


Cyclophosphamide

+ 30% *

+ 13% *

+ 41% *

+ 16%

Azathioprine

+36% *

+ 8%

+ 7%

- 13%

Hydroxychloroquine

+ 81% *

+ 75% *

+ 18%

+ 6%

Methylprednisolone

+ 55% *

+ 26% *

+ 8%

- 9%


Presented are the results of three independent experiments and expressed as % changes of the protein amounts in SP-CI73T cells compared to SP-CWT expressing cells; * denotes p-values < 0.05

Woischnik et al. BMC Cell Biology 2010 11:88   doi:10.1186/1471-2121-11-88

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