Modulation of chaperone level in the cells expressing SP-CWT and SP-CI73T by pharmacologic substances. Shown is the fold change in protein level of the chaperone proteins HSP90, HSP70, calreticulin and calnexin in MLE-12 cells expressing proSP-CWT and proSP-CI73T before and after their exposure to the drugs commonly applied in ILD therapy: (A) hydroxychloroquine, (B) methylprednisolone, (C) azathioprine and (D) cyclophosphamide. Only significant p-values are presented.
Woischnik et al. BMC Cell Biology 2010 11:88 doi:10.1186/1471-2121-11-88