Viability of MLE12 cells expressing SP-CWT or SP-CI73T before and after treatment with drugs used in therapy. MLE-12 cells stably expressing SP-CWT or SP-CI73T were incubated 24 hours with 10 μM of cyclophosphamide (+Cyc), azathioprine (+Aza), methylprednisolone (+Met), or hydroxychloroquine (+Hyd). LDH release, a sign of deceased cell fitness, of treated vs. untreated (-) cells is expressed as % of total LDH. Only significant p-values are depicted.
Woischnik et al. BMC Cell Biology 2010 11:88 doi:10.1186/1471-2121-11-88