Open Access Research article

A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling

Markus Woischnik1, Christiane Sparr1, Sunčana Kern1, Tobias Thurm1, Andreas Hector1, Dominik Hartl1, Gerhard Liebisch2, Surafel Mulugeta3, Michael F Beers3, Gerd Schmitz2 and Matthias Griese1*

Author Affiliations

1 Department of Pneumology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians University, Lindwurmstr. 4, Munich, 80337, Germany

2 Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg, 93053, Germany

3 Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, 380 S. University Avenue, Philadelphia, PA 19104, USA

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BMC Cell Biology 2010, 11:88  doi:10.1186/1471-2121-11-88

Published: 20 November 2010

Additional files

Additional file 1:

Table S1. Phospholipid classes and molecular species profile of transfected MLE-12 cells stably expressing SFTPC I73T mutation. Data are means and standard deviation of three independent experiments, each performed in duplicate. The mutant (I73T) and wild type (WT) were compared by ANOVA followed by Tukeys multiple comparison test. P-values are shown.

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