Structural model illustrating the conservation of amino acids that create the NLS binding surface in KPNA proteins. The ClustalW alignment of KPNA2 and KPNA7 (Top panel) or all of the KPNA's (bottom panel) was used to map identical (cyan), conserved (blue), and different (gray) residues onto the importin α/RB NLS (Red) structure 1PJM . The left image is rotated 90° and shown on the right. Images were created using Pymol http://www.pymol.org/ webcite.
Kelley et al. BMC Cell Biology 2010 11:63 doi:10.1186/1471-2121-11-63