Open Access Highly Accessed Research article

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

Ananthamurthy Nagabhushana1, Madhavi L Chalasani2, Nishant Jain1, Vegesna Radha1, Nandini Rangaraj1, Dorairajan Balasubramanian2 and Ghanshyam Swarup1*

Author Affiliations

1 Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad - 500 007, India

2 L.V. Prasad Eye Institute, Hyderabad - 500 034, India

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BMC Cell Biology 2010, 11:4  doi:10.1186/1471-2121-11-4

Published: 19 January 2010

Additional files

Additional file 1:

Dynamics of vesicles formed by GFP-optineurin. HeLa cell transfected with GFP-OPTN was imaged by time lapse video microscope. Images were acquired every 12 sec for 15 min and played at 5 frames per second. Movie shows the movement of vesicles. Bar, 5 μm.

Format: MOV Size: 4.6MB Download file

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Open Data

Additional file 2:

Dynamics of vesicles formed by GFP-E50K. Images were acquired every 12 sec for 15 min and played at 5 frames per second. Movie shows the movement of vesicles with occasional fusion of smaller vesicles with larger vesicles in the perinuclear region. Bar, 5 μm.

Format: MOV Size: 4.1MB Download file

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Open Data