Effect of hypoxia on chromosomal stability. Chromosomal aberrations were not detectable by high-resolution matrix-based comparative genomic hybridization after 4 weeks of MSC culture at 21% O2 and 1% O2. Except for typical polymorphisms, the DNA of MSC did not show any chromosomal abnormalities compared to freshly isolated DNA from PBMC of healthy volunteers (n = 3).
Holzwarth et al. BMC Cell Biology 2010 11:11 doi:10.1186/1471-2121-11-11