Table 2

Strain-induced pathway-specific quantitative mRNA-expression changes in PDL cells

gene symbol

relative gene expression value

gene symbol

relative gene expression value

gene symbol

relative gene expression value

gene symbol

relative gene expression value

gene symbol

relative gene expression value


extracellular matrix and integrin pathway

growth factor pathway

growth factor pathway

growth factor pathway

MAP-Kinase signalling and cell cycle pathway

COL11A1

2.08

BMP1

-2.07

FGF11

2.14

GDF8

10.56

CCNA1

2.38

COL14A1

-5.43

BMP2

-36.76

FGF14

6.06

GDNF

-5.28

CCNB1

2.07

COL1A1

-6.23

BMP4

5.66

FGF17

4.00

IGF1

-8.00

CDKN2A

3.73

COL4A2

-2.06

BMP5

3.73

FGF2

-17.15

IL11

-10.20

CDKN2C

2.14

HAS1

-2.53

BMP6

-4.29

FGF22

5.10

IL12B

2.38

EGR1

9.85

ITGA3

2.75

BMP7

2.46

FGF23

2.30

IL18

3.73

FOS

59.89

ITGA8

-2.06

CSF1

-4.44

FGF6

4.76

IL1A

-8.00

MAP2K6

8.28

MMP10

-6.68

CSF2

-22.63

FGF7

-14.93

IL1B

-42.22

MAP4K1

4.92

MMP12

6.32

CSF3

-17.75

FGF9

3.25

IL2

6.06

MAPK6

5.86

MMP13

2.51

CXCL1

-115.36

GDF10

2.30

SPP1

3.36

MAPK8IP2

10.58

ECGF1

-12.13

TGFB1

-3.86

EREG

-26.91

VEGFA

-5.86

VEGFC

-2.38


Values of relative increase or decrease in gene expression represent the mean of two independent RT-Profiler experiments and were normalised using an experimental internal index of housekeeping genes. All expression values above 2 and below -2 were considered per definition as significantly modulated compared with unstrained basal control expression of the respective gene on each RT-Profiler.

Ziegler et al. BMC Cell Biology 2010 11:10   doi:10.1186/1471-2121-11-10

Open Data