Occludin and occludin disrupting molecules. The general topology of the tetraspanin molecule occludin and the FLAG tagged truncated fragment used to make the truncated molecule, F-ΔOcc, are shown in diagrammatic format along with the location of an occludin disrupting peptide. COOH, C-terminus; PM, plasma membrane; F, FLAG epitope tag; rs, restriction site used to make truncated occludin; LYHY, conserved peptide sequence used in later experiments.
Beeman et al. BMC Cell Biology 2009 10:85 doi:10.1186/1471-2121-10-85