Model for the role of PTH mRNA interacting proteins in PTH mRNA stability. PTH mRNA stability is regulated through the interaction of AUF1, Unr and KSRP with the PTH mRNA 3'-UTR ARE (light green) [1-3]. KSRP, the exosome and PMR1 are recruited to PTH mRNA through KSRP-exosome interaction leading to decreased PTH mRNA stability and levels. PMR1-PTH mRNA association may be mediated by additional unidentified binding protein/s (PMR1-BP).
Nechama et al. BMC Cell Biology 2009 10:70 doi:10.1186/1471-2121-10-70