The chromosomal aberrations in IMR-90 and U251 cells. Metaphase spreads from the untreated cells show no apparent damage in the chromosomes (A), Ag-np treated IMR-90 cells show acentric and centric fragments (B). Arrow indicates acentric fragments. (C) Untreated cancer cells with no aberrations, metaphases show dicentric chromosomes in untreated cells (D) and treated cells. White arrow points to a dicentric chromosome. Cancer cells treated with Ag-np also show acentric fragments (E) and centric fragments (F). Red arrow points to a chromosome fragment. (G) Summary of the frequency of aberrations observed in Ag-np treated cells. A minimum of 50 metaphases per sample was scored for the chromosome analysis.
AshaRani et al. BMC Cell Biology 2009 10:65 doi:10.1186/1471-2121-10-65