Human fibroblasts induce collagen lattice contraction in a similar manner as murine firoblasts. A. Means and 95% confidence intervals for collagen lattice areas as observed over seven days are given for primary cultures from human fibroblasts treated with lithium, Dkk-1, TGF-β, or a carrier. There is a statistically significant difference for TGF-β treatment compared to carrier after day three. For lithium treatment there is a statistically significant difference for the time points with an asterisk above the data points. B. Representative photographs of the collagen lattices at day five.
Poon et al. BMC Cell Biology 2009 10:38 doi:10.1186/1471-2121-10-38