Figure 6.

(A) The effect of compound 1 on the regression of established BAEC tubular networks. Cells were treated with FGF-2 on matrigel until an established tubular network was visible. The test compounds were added in serum and after 24 h the number of closed areas was counted as described below. The results are the mean of three experiments and values differing from the control are shown by *. (B) Representative photomicrographs of tubular structures shown for FGF-2 alone (control; panel I) and in the presence of compound 1 (panel II) show tubular regression in the presence of the test compound (original magnification × 20).