Figure 4.

ROC curves for the sequence-based predictor. ROC curves for the sequence-based predictor. The cross-validation True Positive Rate (TPR) versus the False Positive Rate (FPR) are plotted the best method (SVM-WIN31) and for the baseline method (SVM-BASE). In part (A) the ROC curves of the two methods are relative to the prediction of increasing and decreasing free energy mutations (|ΔΔG|>1.0 kcal/mole), while in part (B) they are calculated for neutral mutations (|ΔΔG|≤1.0 kcal/mole).