Resolution:
## Figure 8.
Schematic of cutting strategies and spanning clusters. Leaves of the binary tree,
e.g. domains, are numbered 1 to 12. In the figure, it is assumed that four clusters
(1,2,3), (7, 8, 9) and (12) are from one particular fold and the three clusters (4,
5, 6), (10) and (11) contain all 5 domains of another fold. Horizontal line A – A
represents the level cut, which produces a partition of 7 clusters but which splits
the cluster (1,2,3) into two clusters, (1,2) and (3). Oblique line B – B is an allowable
cut which produces a partition of 6 clusters and does not split (1,2) from (3). The
node n1 represents the spanning cluster of the fold having domains 4, 5, 6, 10 and
11. The span, or size, of this spanning cluster is nine, and its excess span, or number
of included domains not in this fold, is four. The node labelled n2, spanning three
domains, namely 4, 5, and 6, represents the largest homogeneous cluster of this fold.
For this fold, the relative size of the largest homogeneous cluster is 3/5, e.g. the
size of the largest homogeneous cluster divided by the size of the associated fold.
Sam |