|
Average Type I error rate (empirical α) when nominal α is 0.05 |
|||||||||||
| Set Size |
True mean log-ratio of genes in the set |
Standard deviation of log-ratios of genes in the set |
GSEA-NR |
ABSSUM-NR |
SUMSQ-NR |
SUM-NR |
MAX-MEAN-NR |
FET 1/2 |
FET 1 |
FET 2 |
FET 3 |
|
|
|||||||||||
| 2–5 genes |
0 |
0.01–0.05 |
0.0005 |
0 |
0 |
0.056 |
0 |
0 |
0 |
0 |
0 |
| 0.10–0.20 |
0.005 |
0.001 |
0.0006 |
0.058 |
0.002 |
0.0004 |
0 |
0 |
0 |
||
| ± 0.05 |
0.01–0.05 |
0.02 |
0 |
0 |
0.056 |
0 |
0 |
0 |
0 |
0 |
|
| 0.10–0.20 |
0.01 |
0.002 |
0.0008 |
0.06 |
0.003 |
0.0005 |
0 |
0 |
0 |
||
| 10 or more genes |
0 |
0.01–0.05 |
0.29 |
0 |
0 |
0.13 |
0 |
0 |
0 |
0 |
0 |
| 0.10–0.20 |
0.03 |
0.004 |
0 |
0.14 |
0.0005 |
0.0001 |
0 |
0 |
0 |
||
| ± 0.05 |
0.01–0.05 |
0.45 |
0 |
0 |
0.15 |
0 |
0 |
0 |
0 |
0 |
|
| 0.10–0.20 |
0.08 |
0.006 |
0 |
0.15 |
0.004 |
0.0002 |
0 |
0 |
0 |
||
Tintle et al. BMC Bioinformatics 2008 9:469 doi:10.1186/1471-2105-9-469 |
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