Figure 8.

Multi-dimensional perspective of chromosome 17 of the HCC2218 breast cancer cell line. Copy number, LOH, and DNA methylation, and profiling identifies an amplification of ERBB2 coinciding with allelic imbalance and loss of methylation. When examining the gene expression, the expression of HCC2218 is significantly higher than a panel of normal luminal and myoepithelial cell lines [29].