Classification of the Multiple Behaviours Modules (MBM) found in S. cerevisiae transcriptional network. Green and red interactions correspond to inferred activations and repressions respectively. Significant differentially expressed genes of the MBM, during one experimental condition, are coloured green (up-regulated), or red (down-regulated) (a) Type I modules are composed by regulations towards the same gene. Regulations in this module were found to be inconsistent in at least 2 experiments. (b) Type II are composed by genes regulated by the same direct predecessor. Explanation: The interaction among Sum1 and YFL040W is inferred at the Step 1 of the algorithm as an activation, while among Sum1 and DIT2 as an inhibition. During the correction step (Step 2), expression profiles related to one experiment showed that the expression of these two genes (YFL040W and DIT2) is up-regulated. As it is impossible to state if SUM1 is up or down-regulated (inconsistency), we mark this module as MBM. (c) Type III are composed by coloured genes that share a predecessor. (d) Type IV are composed by coloured genes sharing the same predecessor or successor.
Veber et al. BMC Bioinformatics 2008 9:228 doi:10.1186/1471-2105-9-228