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This article is part of the supplement: Otto Warburg International Summer School and Workshop on Networks and Regulation

Open Access Highly Accessed Review

Graphs in molecular biology

Wolfgang Huber1*, Vincent J Carey2, Li Long3, Seth Falcon4 and Robert Gentleman4

Author Affiliations

1 European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge CB10 1SD, UK

2 Channing Laboratory, Brigham and Women's Hospital, 75 Francis Street, Boston MA 02115, USA

3 Vital-IT Center, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland

4 Fred Hutchinson Cancer Research Center, Computational Biology Group, 1100 Fairview Avenue North – M2-B876, P.O. Box 19024, Seattle WA 98109-1024, USA

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BMC Bioinformatics 2007, 8(Suppl 6):S8  doi:10.1186/1471-2105-8-S6-S8

Published: 27 September 2007

Abstract

Graph theoretical concepts are useful for the description and analysis of interactions and relationships in biological systems. We give a brief introduction into some of the concepts and their areas of application in molecular biology. We discuss software that is available through the Bioconductor project and present a simple example application to the integration of a protein-protein interaction and a co-expression network.