Table 1

Motifs significantly associated with gene expression changes in long lived mutants, sch9Δ, ras2Δ, and tor1Δ, with respect to the wild-type yeast.



sch9Δ/wt
ras2Δ/wt
tor1Δ/wt
TF
Consensus
AC
p-value
q-value
AC
p-value
q-value
AC
p-value
q-value

Fhl1
RTGT-YGGRTG
17.0
0
0
12.4
0
0
16.0
0
0
Msn2/4
AGGGG
15.0
0
0
15.4
0
0
12.5
0
0
Gis1
AWAGGGAT
12.0
0
0
12.5
0
0
10.6
0
0
Sum1/Ndt80
GACACAAAA
8.7
0
0
9.3
0
0
9.2
0
0
Pho4
GY-TSKCACGTG-G
7.3
0.0006
0.0013
9.5
0
0
8.7
0.0006
0.0025
Pdr3
S-TCCGYGGAA
6.0
0.011
0.012
9.1
0.0006
0.0009
4.4
0.067
0.077
Cad1
ATTAGTAAGC
5.9
0.014
0.015
8.5
0.0006
0.0009
4.6
0.033
0.048
Mig1
CGCATMCCCCAC
5.2
0.037
0.029
7.8
0
0
5.6
0.053
0.066
Met31
MWGTGTGGCR
4.9
0.041
0.031
9.2
0
0
5.4
0.047
0.061
Hsf1
GAW-TTCTAGAA
4.3
0.16
0.083
9.1
0
0
4.6
0.087
0.091
Zap1
ACCYT-AGGTT
3.8
0.43
0.16
12.1
0
0
5.2
0.045
0.059
Met4
AMAA-TGTGG
3.4
0.45
0.16
9.8
0
0
5.8
0.054
0.067
Cbf1
RRTCACGTG
3.3
0.45
0.16
9.2
0
0
5.3
0.038
0.054
Swi4
CRCGAAAA
3.2
0.39
0.15
3.5
0.27
0.080
11.8
0
0
Abf1
CGT|-ARTGAT
-5.2
0.033
0.027
-9.3
0
0
-9.2
0
0
Xbp1
GCCTCGARGMGR
-7.1
0
0
4.4
0.24
0.075
-3.3
0.21
0.17

The 16 motifs that can be associated with a known TF and are significant in at least one of the three long-lived mutants are shown.

Cheng et al. BMC Bioinformatics 2007 8:452   doi:10.1186/1471-2105-8-452