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Summary of subfamilies identified within the NSS family.1 |
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| Subfamily Designation |
Description |
Number of Sequences |
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|
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| Osmolytes |
Two distinct groups of GABA transporters (11 and 12, respectively). Also includes: creatine (6), taurine (9), and betaine transporters (6). Two remain ORFans. |
46 |
| Biogenic amines |
Two distinct groups of dopamine transporters (13 and 6, respectively). Also includes: norepinephrine (13), epinephrine (1), and serotonin (11) transporters. |
44 |
| Renal system |
Only 7 sequences are characterized, of which: 5 are isolated from the renal system; 1 is an intestinal brush border proline transporter; and the last was found in the brain. Due to the location of the branch point, the sequences highlighted in dark purple in Figure 1 are also included; however, no experimental evidence is available to confirm or refute this. |
24 |
| Amino acid #1 |
Mainly includes proline (5) and glycine (10) transporters; 3 are generically annotated as "amino acid" transporters. |
18 |
| Amino acid #2 |
3 generically annotated as "amino acid" transporters and 2 ORFans. |
5 |
| Prokaryotic |
Bacterial and archaeal transporters (includes LeuTAa). Nearly all are from genome sequencing projects and lack robust biophysical characterization of functional specificity. |
44 |
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1 An exact summary of all experimentally characterized and ORFan sequences are provided in Additional file 1. | ||
Livesay et al. BMC Bioinformatics 2007 8:397 doi:10.1186/1471-2105-8-397 |
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