Correlation between experimental ln(kcat/Km) for bisphosphate and electrostatic potential differences for different aldolases (a) and prediction of kcat/Km for bisphosphate and class I aldolase (b). Correlations (a) are for differences in ln(kcat/Km) and electrostatic potential differences of each aldolase protein pair, after excluding ALF2_LAMJA and ALDOC_RAT. Predictions presented on part (b) were made for 8 aldolases based on ALDOB_RABIT and Q9U5N6_LEIME experimental parameters. Two outliers (with errors greater than 1.5 RMS deviation from y = x) are labeled, see text for discussion.
Gabdoulline et al. BMC Bioinformatics 2007 8:373 doi:10.1186/1471-2105-8-373