Ten mammalian PPI network datasets were consolidated into one dataset, and then filtered by excluding interactions originating from articles that contributed many interactions, or by excluding interactions with few references. The filtered merged dataset is then used to analyze lists of gene or protein names by outputting a subnetwork with nodes in three different colors: seed, significant, insignificant. The output also includes a statistical report that ranks intermediate nodes based on their specificity to interact with the seed list.
Berger et al. BMC Bioinformatics 2007 8:372 doi:10.1186/1471-2105-8-372