|
Evolutionary conservation of uORFs highlighted by Vilela and McCarthy [3]. Genes with conserved uORFs are shown in bold. |
|||
| Gene |
uORF conservation1 |
If predicted not to be functional, reason for this |
Evidence about functional role |
|
|
|||
| CLN3 |
yes (1/1; 4/6) |
[26] |
|
| GCN4 |
yes (4/4; 7/7) |
[6] |
|
| INO2 |
no (0/1; 0/6) |
uORF too long |
|
| PPR1 |
no (0/1; 0/6) |
uORF too close to main AUG |
|
| SCO1 |
no (0/1; 0/5) |
uORF too close to main AUG |
[32]2 |
| CPA1 |
yes (1/1; 5/5) |
[4] |
|
| HAP4 |
yes (2/2; 4/4) |
[43]3 |
|
| LEU4 |
no (0/1; 0/7) |
uORF too close to main AUG |
|
| TIF4631 |
yes (4/6; 4/6) |
[31]3 |
|
| YAP1 |
yes (1/1; 3/5) |
[27] |
|
| YAP2 |
yes (2/2; 3/3) |
[27] |
|
| CBS1 |
no (0/1; 0/5) |
uORF too close to main AUG |
[32]2 |
| DCD1 |
no (0/1; 0/7) |
uORF too close to main AUG |
|
| HOL1 |
yes (1/1; 4/4) |
[29] |
|
| PET111 |
yes (3/4; 3/4) |
[30]4 |
|
| SCH9 |
no (0/1; 0/6) |
uORF too long (55 codons) |
|
|
The STA1-3 genes mentioned by Vilela and McCarthy are not present in the standard S288c genome sequence and were not included in this analysis. 1 Numbers between parentheses denote: (number of uORFs conserved/total number of uORFs; number of species where uORFs are conserved/total number of species where orthologue could be identified) 2 Evidence against translational control by uORFs 3 Evidence for translation using an IRES mechanism 4 Pet111 controls translation of another mRNA, but no evidence for uORF control of PET111 expression | |||
Cvijović et al. BMC Bioinformatics 2007 8:295 doi:10.1186/1471-2105-8-295 |
|||