The dependence of function divergence on sequence divergence for the EF-hand family in which the proteins with only the experimentally supported annotations were utilized. Abscissa: GO Distance; Ordinate: fraction of comparisons. Different colors show distributions of sets of pairs of proteins with different ranges of sequence similarity, divided into ranges of width 10% residue identity.
Sangar et al. BMC Bioinformatics 2007 8:294 doi:10.1186/1471-2105-8-294