Table 3 |
||||
|
Functional modules and informative proteins found in the yeast interaction network |
||||
|
module ID |
module size |
informative proteins |
function |
-log(p-value) |
|
|
||||
|
2 |
81 |
YLR147c, YGR091w |
mRNA processing – splicing |
59.88 |
|
3 |
240 |
YBR160w |
mitotic cell cycle |
35.37 |
|
4 |
63 |
YER012w |
protein degradation – proteasome |
26.48 |
|
5 |
95 |
YDL140c |
mRNA synthesis – general transcription activity |
45.23 |
|
6 |
76 |
YCR093w, YGR134w |
mRNA synthesis – transcriptional control |
32.23 |
|
7 |
90 |
YJR022w, YOL149w |
mRNA processing – splicing |
50.30 |
|
13 |
89 |
YGR119c |
nuclear transport |
48.42 |
|
18 |
67 |
YDR448w |
mRNA synthesis – transcriptional control |
42.64 |
|
19 |
21 |
YJR121w |
energy generation |
28.35 |
|
24 |
50 |
YGR013w |
mRNA processing – splicing |
57.60 |
|
27 |
74 |
YOR181w |
actin cytoskeleton |
29.85 |
|
28 |
65 |
YGL172w |
RNA transport |
44.04 |
|
29 |
30 |
YLR127c, YDR118w |
protein modification – ubiquitination |
29.58 |
|
39 |
65 |
YLR347c |
nuclear transport |
57.92 |
|
47 |
75 |
YLR229c |
budding and cell polarity |
44.52 |
|
61 |
53 |
YGL092w |
structural protein binding |
24.01 |
|
63 |
40 |
YPR181c |
vesicular transport – ER to Golgi transport |
39.22 |
|
65 |
41 |
YKL145w |
protein modification – proteolytic processing |
29.89 |
|
71 |
58 |
YBL050w |
vesicular transport – vesicle fusion |
26.75 |
|
76 |
36 |
YBR088c |
DNA repair |
23.09 |
|
78 |
48 |
YLR335w |
nuclear transport |
49.21 |
|
83 |
46 |
YJL041w |
RNA transport |
42.93 |
|
89 |
28 |
YPR041w |
protein synthesis – translation initiation |
36.63 |
|
95 |
36 |
YIL109c |
vesicular transport – ER to Golgi transport |
41.47 |
|
109 |
52 |
YER172c |
mRNA processing – splicing |
53.47 |
|
101 |
24 |
YGL153w |
peroxisome creation |
24.57 |
|
111 |
23 |
YDR244w |
peroxisomal transport |
26.33 |
|
122 |
62 |
YHR165c |
mRNA processing – splicing |
59.90 |
|
141 |
24 |
YBL023c |
DNA synthesis – ori recognition |
29.35 |
|
151 |
31 |
YOR076c |
nucleotide metabolism – RNA degradation |
31.01 |
|
153 |
39 |
YDR227w |
DNA modification – DNA conformation |
24.55 |
|
161 |
28 |
YLR175w |
rRNA processing |
21.22 |
|
181 |
33 |
YOR121w |
transmembrane signal transduction |
17.46 |
|
183 |
23 |
YNL102w |
DNA synthesis – polymerization |
16.01 |
|
185 |
10 |
YDR016c |
cell cycle – chromosomal cycle |
14.49 |
|
|
||||
|
Flow-based modularization algorithm was implemented with 200 informative proteins and 0.1 as a minimum flow threshold. The input network was weighted by semantic interactivity. 35 output modules are listed with their informative proteins, functions and -log(p-value). Some modules have two informative proteins because they were merged during the post-process. |
||||
|
Cho et al. BMC Bioinformatics 2007 8:265 doi:10.1186/1471-2105-8-265 |
||||
