Artificial neural network models for prediction of intestinal permeability of oligopeptides
1 Insilicotech Co. Ltd., A-1101 Kolontripolis, 210, Geumgok-Dong, Bundang-Gu, Seongnam-Shi, 463-943, Korea
2 SBScience Co. Ltd., Sung-Ok BD, Sunae-Dong, Bundang-Gu, Seongnam-Shi, 463-825, Korea
3 Department of Chemistry, Korea University, 1, Anam-dong 5-Ga, Seongbuk-Gu, Seoul, 136-701, Korea
4 School of Agriculture Biotechnology, Seoul National University, San56-1, Shilim-Dong, Kwanak-gu, 151-742, Korea
BMC Bioinformatics 2007, 8:245 doi:10.1186/1471-2105-8-245Published: 11 July 2007
Oral delivery is a highly desirable property for candidate drugs under development. Computational modeling could provide a quick and inexpensive way to assess the intestinal permeability of a molecule. Although there have been several studies aimed at predicting the intestinal absorption of chemical compounds, there have been no attempts to predict intestinal permeability on the basis of peptide sequence information. To develop models for predicting the intestinal permeability of peptides, we adopted an artificial neural network as a machine-learning algorithm. The positive control data consisted of intestinal barrier-permeable peptides obtained by the peroral phage display technique, and the negative control data were prepared from random sequences.
The capacity of our models to make appropriate predictions was validated by statistical indicators including sensitivity, specificity, enrichment curve, and the area under the receiver operating characteristic (ROC) curve (the ROC score). The training and test set statistics indicated that our models were of strikingly good quality and could discriminate between permeable and random sequences with a high level of confidence.
We developed artificial neural network models to predict the intestinal permeabilities of oligopeptides on the basis of peptide sequence information. Both binary and VHSE (principal components score