ROC curves for the prediction of interacting and non-interacting protein binding sites using different input features. (a) Predictions using only sequence profile/sequence information but different surface patch or sequence window sizes. Predictions using different combinations of sequence profile, secondary structure, and ASA when (b) surface patch size is 1 (c) surface patch size is 3. SEQ: sequence profile; SEQ-NE: sequence information only (without the evolutionary information provided by homologous sequences); SEC: secondary structure; ASA: accessible surface area.
Chung et al. BMC Bioinformatics 2007 8:223 doi:10.1186/1471-2105-8-223