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Overview of the evaluated normalization methods. The compared normalization methods and their corresponding properties. a The spatial effect is constrained to print-tip based effects. b The method can be extended to support this feature. |
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| Method name |
Short name |
Ratio-based |
Spatial |
Between-array |
|
|
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| Global median |
Median |
Yes |
No |
No |
| Global loess |
Loess |
Yes |
No |
No |
| Print-tip loess |
PT-loess |
Yes |
Yesa |
No |
| Print-tip loess with Tquantile norm. |
PT-loess/Tq |
Yes/Yes |
Yesa/No |
No/Yes |
| OLIN |
OLIN |
Yes |
Yes |
No |
| VSN |
VSN |
No |
Nob |
No |
| Global loess with ANOVA |
ANOVA |
Yes/No |
No/Yes |
No/Yes |
| OPLS |
OPLS |
No |
Yes |
Yes |
Bylesjö et al. BMC Bioinformatics 2007 8:207 doi:10.1186/1471-2105-8-207 |
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