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Simulating genetic perturbation and its effects on LDH release |
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| Probability of LDH Release |
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|
|
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| Gene |
Level |
Low |
High |
|
|
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| SCD |
low |
0.33 |
0.67 |
| high |
0.65 |
0.35 ↓ |
|
| NF-KB |
low |
0.47 |
0.53 |
| high |
0.77 |
0.23↓ |
|
| PKR |
low |
0.65 |
0.25↓ |
| high |
0.57 |
0.43 |
|
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The probability of LDH release taking on a high or low level in the palmitate cultures. BN inference was used to conduct the simulations of up-regulation of SCD, down-regulation of PKR, and up-regulation of NF-KB. "↓" indicates decreased probability and "↑" indicates increased probability. | |||
Li et al. BMC Bioinformatics 2007 8:202 doi:10.1186/1471-2105-8-202 |
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