Table 2

Breast cancer-related genes. Genes with multivariate expression patterns discovered by the RIT algorithm for the breast cancer data.

Gene

Status

Function

Ref. (PMID)

Anln

C

Over-expressed in diverse common human tumors, may have potential as biomarker.

16203764

Aurka

B

Cell cycle-regulated kinase, possible prognostic indicator for patients with breast tumors.

12833450

Aurkb

C

Highly expressed in high-grade gliomas, correlated with malignancy and clinical outcomes.

15072448

Birc5

B

Prevents apoptotic cell death, differentially expressed in breast cancer.

16142334

Blm

C

Cooperates with p53 in regulation of cell growth, associated with colorectal cancer.

11781842, 12242432

Brrn1

CC

Required for the conversion of interphase chromatin into condensed chromosomes.

Bub1

C

Mutations in this gene have been associated with aneuploidy and several forms of cancer.

15931389

Ccnb1

B

Detected in various human breast cancer cell lines and breast tumor tissues.

11779217

Ccnb2

CC

Essential component of the cell cycle regulatory machinery.

Cdc20

C

Regulatory protein in the cell cycle, associated with gastric cancer.

15701830

Cdc25A

C

Known oncogene, required for progression from G1 to the S phase of the cell cycle.

14673957

Cdc45L

CC

Important for early steps of DNA replication in eukaryotes, loss may affect cell proliferation.

9660782

Cdca8

CC

Required for stability of the bipolar mitotic spindle.

Depdc1

N

Contains domain of unknown function often present together with the RhoGAP domain.

Depdc1B

N

Unknown function, has conserved RhoGAP domain (GTPase-activator protein).

Dlg7

C

Potential oncogenic target of AURKA, may play a role in human carcinogenesis.

15987997, 12527899

Exo1

C

Possible cancer predisposing gene.

15328369

Fam64A

N

Unknown function.

Fbxo5

CC

Function in ubiquitination, inhibits the anaphase promoting complex.

Foxm1

C

Stimulates the proliferation of tumor cells.

16489016

Gpr116

N

Has two immunoglobulin-like repeats, may have a role in the immune system.

12435584

H2Afz

C

Chromatin remodeling at the c-myc oncogene involves the local exchange of this histone.

15878876

Hist1H1B

N

Histone protein.

Hist1H1E

N

Histone protein.

Hist1H4B

N

Histone protein.

Kif20A

C

Required for cytokinesis, related to AURKB. Likely to be involved in pancreatic cancer.

15263015, 15665285

Kif23

CC

Interacts with CYK4, to form the centralspindlin complex. Essential for cell division.

11782313

Kif2C

CC

Important for anaphase chromosome segregation.

Kifc1

CC

Involved in localization of PLK1, AURKB, and CDC14A during anaphase.

15263015

Mad2L1

C

Mitotic checkpoint gene, involved mainly in colorectal carcinogenesis.

12970887

Nek2

B

Significantly up-regulated in breast carcinomas.

15492258

Pitrm1

N

Novel member of the metalloendoprotease superfamily.

10360838

Prr11

N

Unknown function. Predicted interactions with E2F, which is involved in cancer.

16437386

Pttg2

C

Potent oncogene, expressed at high levels in various human tumors and tumor cell lines.

10806349

Racgap1

B

Implicated in in breast cancer cell proliferation

15863513

Rad54L

B

Candidate oncosupressor in breast or colon carcinomas, lymphomas and meningiomas.

12614485

Spbc25

CC

Essential kinetochore component, significant role in mitotic events

14699129

Stil

C

Involved in mitosis and in increased mitotic activity in tumor cells.

Tk1

C

Marker for non-small cell lung cancer. May be important in epithelial ovarian cancer.

15809747, 11992400

Tpx2

C

May be important in both progression lung cancer, possible prognostic predictor.

16489064

Ttk

CC

Required for centrosome duplication and for the normal progression of mitosis.

15618221, 14657364

Ube2C

C

Required for destruction of mitotic cyclins. Highly expressed in human primary tumors.

12874022

Ube2S

N

Essential component of the ubiquitin-protein conjugation system.

15454246

Status column: B, Breast cancer-specific; C, Cancer-related; CC, Cell cycle-related; N, novel.

Nilsson et al. BMC Bioinformatics 2007 8:150   doi:10.1186/1471-2105-8-150