Database

UbiProt: a database of ubiquitylated proteins

Alexander L Chernorudskiy¹ , Alejandro Garcia² , Eugene V Eremin³ , Anastasia S Shorina² , Ekaterina V Kondratieva² and Murat R Gainullin²

¹Nizhny Novgorod State University, 23 Gagarin Ave., Nizhny Novgorod, Russia

²Central Research Laboratory, Nizhny Novgorod State Medical Academy, 10/1 Minin Sq., Nizhny Novgorod, Russia

³Institute of Applied Physics RAS, 46 Ul'yanov St., Nizhny Novgorod, Russia

author email corresponding author email

BMC Bioinformatics 2007, 8:126doi:10.1186/1471-2105-8-126

Published:	18 April 2007

Abstract

Background

Post-translational protein modification with ubiquitin, or ubiquitylation, is one of the hottest topics in a modern biology due to a dramatic impact on diverse metabolic pathways and involvement in pathogenesis of severe human diseases. A great number of eukaryotic proteins was found to be ubiquitylated. However, data about particular ubiquitylated proteins are rather disembodied.

Description

To fill a general need for collecting and systematizing experimental data concerning ubiquitylation we have developed a new resource, UbiProt Database, a knowledgebase of ubiquitylated proteins. The database contains retrievable information about overall characteristics of a particular protein, ubiquitylation features, related ubiquitylation and de-ubiquitylation machinery and literature references reflecting experimental evidence of ubiquitylation. UbiProt is available at http://ubiprot.org.ru webcite for free.

Conclusion

UbiProt Database is a public resource offering comprehensive information on ubiquitylated proteins. The resource can serve as a general reference source both for researchers in ubiquitin field and those who deal with particular ubiquitylated proteins which are of their interest. Further development of the UbiProt Database is expected to be of common interest for research groups involved in studies of the ubiquitin system.