BMC Bioinformatics

official impact factor 3.03

Open Access Highly Access Research article

Rapid and asymmetric divergence of duplicate genes in the human gene coexpression network

Wen-Yu Chung1,6, Reka Albert2, Istvan Albert5, Anton Nekrutenko3,5,6 and Kateryna D Makova4,6*

Author Affiliations

1 Department of Computer Science and Engineering, Penn State University, University Park, PA, 16802, USA

2 Department of Physics, Penn State University, University Park, PA, 16802, USA

3 Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA, 16802, USA

4 Department of Biology, Penn State University, University Park, PA, 16802, USA

5 Department of Huck Institute for Life Sciences, Penn State University, University Park, PA, 16802, USA

6 Department of Center for Comparative Genomics and Bioinformatics, Penn State University, University Park, PA, 16802, USA

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BMC Bioinformatics 2006, 7:46 doi:10.1186/1471-2105-7-46

Published: 27 January 2006

Additional files

Additional File 1:

The numerical description of the networks

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Additional File 2:

Degree distributions of networks generated from a combination of thresholds: T (tissue) and R (Pearson correlation coefficient). The degree distribution for the network with T ≥ 7 and R ≥ 0.7 is shown in Figure 1

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Additional File 3:

The scatter plots between clustering coefficient c and node degree k for (A) all genes, (B) ubiquitously expressed genes, and (C) nonubiquitously expressed genes.

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Additional File 4:

The degree distribution of the studied network (T ≥ 7 and R ≥ 0.7) for (A) duplicate genes and (B) singletons.

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Additional File 5:

Scripts for the study

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Additional File 6:

Network binary matrix.

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Additional File 7:

The set of independent duplicate gene pairs.

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