Software
RDMAS: a web server for RNA deleterious mutation analysis
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* Corresponding authors: Xiaochen Bo boxc@bmi.ac.cn - Shengqi Wang sqwang@bmi.ac.cn
- † Equal contributors
1 Beijing Institute of Radiation Medicine, Beijing 100850, China
2 Beijing Institute of Health Administration and Medicine Information, Beijing 100850, China
3 College of Electro-Mechanic and Automation, National University of Defense Technology, Changsha, Hunan 410073, China
4 Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China
BMC Bioinformatics 2006, 7:404 doi:10.1186/1471-2105-7-404
Published: 6 September 2006Abstract
Background
The diverse functions of ncRNAs critically depend on their structures. Mutations in ncRNAs disrupting the structures of functional sites are expected to be deleterious. RNA deleterious mutations have attracted wide attentions because some of them in cells result in serious disease, and some others in microbes influence their fitness.
Results
The RDMAS web server we describe here is an online tool for evaluating structural deleteriousness of single nucleotide mutation in RNA genes. Several structure comparison methods have been integrated; sub-optimal structures predicted can be optionally involved to mitigate the uncertainty of secondary structure prediction. With a user-friendly interface, the web application is easy to use. Intuitive illustrations are provided along with the original computational results to facilitate quick analysis.
Conclusion
RDMAS can be used to explore the structure alterations which cause mutations pathogenic, and to predict deleterious mutations which may help to determine the functionally critical regions. RDMAS is freely accessed via http://biosrv1.bmi.ac.cn/rdmas webcite.