Figure 1.

Normalization effect on diagnostic microarrays. The global signal normalization effect resulting from standard normalization protocols applied to diagnostic microarrays: Shown are changes of expression difference, when switching from a large microarray to a diagnostic microarray. The top genes are those genes with the maximal expression difference between TEL-AML versus BCR-ABL and E2A-PBX1. Note, that expression differences on log scale reflect fold changes.