The sub-network diagram of significant proteins and their interactions for eigenvector #106. Each node represents a protein, and each edge an experimental interaction in the GRID database. No interactions were indicated for the four central proteins, but by inference their function should be related. Experimental data indicate that SGS1 can be essential in the absence of TOP1, so possibly these two proteins may substitute functionally for one another, thereby suggesting the additional interactions shown by dotted lines.
Sen et al. BMC Bioinformatics 2006 7:355 doi:10.1186/1471-2105-7-355