Figure 3.

Types of explained responses (a) inferred links (b) general hypotheses. The significant perturbation responses explained by each model are categorized into three types: expression changes explained by paths containing both regulatory and metabolic links (dark blue), flux changes explained by pure metabolic paths (green), flux changes explained by paths containing both regulatory and metabolic links (brown). The model of inferred links contains two feedback links (glucose, ArcA), (acetyl-CoA, ArcA).