Table 1 |
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C. elegans genes known to extend or shorten life span. The list is taken from the Genes database of SAGEKE http://www.sageke.org webcite |
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Life span extension |
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Hsp-6 |
heat shock 70 protein |
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age-1 |
inositol/phosphatidylinositol kinase; signal transduction |
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age-2 |
AGEing alteration |
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che-2 |
G-beta-repeats |
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che-3 |
microtubule motor, dynein ATPase; microtubule-based movement |
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che-11 |
abnormal CHEmotaxis |
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che-13 |
abnormal CHEmotaxis |
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clk-1 |
ubiquinone biosynthesis |
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clk- 2 |
CLocK (biological timing) abnormality |
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clk-3 |
CLocK (biological timing) abnormality |
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daf-2 |
transmembrane receptor protein tyrosine kinase; phosphorylation, hydrogen transport, signalling |
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daf-6 |
abnormal DAuer Formation |
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daf-10 |
abnormal DAuer Formation |
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daf-12 |
steroid hormone receptor; transcription regulation |
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daf-19 |
DNA binding transcription factor; transcription regulation |
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daf-28 |
abnormal DAuer Formation |
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eat-1 |
EATing: abnormal pharyngeal pumping |
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eat-2 |
EATing: abnormal pharyngeal pumping |
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eat-3 |
EATing: abnormal pharyngeal pumping |
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eat-6 |
Na+/K+ ATPase α subunit; cation transport, metabolism |
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eat-13 |
EATing: abnormal pharyngeal pumping |
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glp-1 |
calcium ion binding; cell differentiation |
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gro-1 |
tRNA isopentenyltransferase; tRNA processing |
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ins-1 |
INSulin related |
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ins-18 |
insulin-like growth factor I like; hormone |
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isp-1 |
ubiquinol-cytochrome c reductase, Rieske iron-sulfur protein; electron transport |
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mec-8 |
nucleic acid binding; mechanosensory |
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mes-1 |
protein tyrosine kinase |
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osm-1 |
OSMotic avoidance abnormal |
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osm-3 |
kinesin |
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osm-5 |
aspartic-type endopeptidase; proteolysis and peptidolysis |
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osm-6 |
N-acetyllactosamine synthase |
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pdk-1 |
protein serine/threonine kinase |
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pgl-1 |
P GranuLe abnormality |
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rad-8 |
RADiation sensitivity abnormal/yeast RAD-related |
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sir-2.1 |
DNA binding; transcription regulation, chromatin silencing |
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spe-10 |
defective SPErmatogenesis |
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spe-26 |
MIPP repeats; defective SPErmatogenesis |
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tax-4 |
Cyclic-nucleotide-gated olfactory channel; potassium transport |
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tkr-1 |
G protein coupled receptor; signalling |
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unc-4 |
homeobox protein (otd subfamily); transcription regulation |
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unc-13 |
intracellular signaling cascade |
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unc-26 |
inositol/phosphatidylinositol phosphatase |
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unc-31 |
PH (pleckstrin homology) domain |
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unc-32 |
TJ6/proton pump |
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unc-64 |
syntaxin |
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unc-76 |
UNCoordinated |
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Shortened life span |
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ctl-1 |
CaTaLase |
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daf-16 |
transcription factor |
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eat-7 |
EATing: abnormal pharyngeal pumping |
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fer-15 |
FERtilization defective (abnormal sperm) |
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mev-1 |
Succinate dehydrogenase cytochrome b chain; electron transport, tricarboxylic acid cycle |
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Blei et al. BMC Bioinformatics 2006 7:250 doi:10.1186/1471-2105-7-250 |
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