Additional File 1:

Drosophila Interactions Database table schema. The database consists of two table types, the gene tables on the left and the interaction tables on the right. The gene tables currently include the Fly Gene Attributes table and the Fly Gene Expression table. Gene records in these tables are uniquely identified by their Gene IDs (Flybase_ID, also known as Flybase gene number or FBgn). As described in the text, the interaction tables currently include three tables of predicted binary interactions (Predicted Worm Interologs, Predicted Yeast Interologs, and Genetic Interactions), and three tables for interactions experimentally determined by yeast two-hybrid (YTH) assays (Finley Lab YTH, Curagen YTH, and Hybrigenics YTH). Interaction records are uniquely identified by pairs of Gene IDs. In the case of the predicted interactions, the interaction has no direction or orientation, and there is no significance to whether a gene is listed as "Gene 1" or Gene 2"; each pair of genes is uniquely listed in only one, arbitrary orientation. In the case of the YTH data, on the other hand, each measurement is made with a gene as either the "BD" or the "AD", and thus each interaction has a direction or orientation. Each pair of Gene IDs can be detected as interacting in the BD-AD orientation, the AD-BD orientation, or both. All of the interaction tables share certain common attributes, such as Data_version, Reference, and fields for the number of interactions for each gene. Each table also has table-specific attributes. Definitions of the attributes are available at http://proteome.wayne.edu/PIMdb.html webcite. All attributes are searchable in IM Browser.

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