Open Access Highly Accessed Methodology article

Automatic pathway building in biological association networks

Anton Yuryev*, Zufar Mulyukov, Ekaterina Kotelnikova, Sergei Maslov, Sergei Egorov, Alexander Nikitin, Nikolai Daraselia and Ilya Mazo

Ariadne Genomics Inc, 9700 Great Seneca Hwy, Suite 113, Rockville, MD 20850, USA

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BMC Bioinformatics 2006, 7:171 doi:10.1186/1471-2105-7-171

Published: 24 March 2006

Additional files

Additional file 1:

Rules and rule results for automatic ResNet curation. The automatic curation rules are detailed in the Materials and Methods section. Abbreviations: TF – transcription factors; NR – nuclear receptors. The row order represents the order in which the rules were applied during the automatic curation. Rules named after the control type correspond to the merging of relation of the same type connecting two entities in the same direction but having different effect or mechanism. These rules are described in Materials and Methods section. Percentage in the second column was calculated as fraction of the total relations of the type subjected to the curation rule. Combination of all rules deletes or converts about 30% of all relations in the ResNet database.

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Additional file 2:

Protein classification in ResNet and its correspondence to GO annotation.

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Open Data