Table 2

Uniquely over-represented functional categories for DEGs obtained from each probe set algorithm from the experimental diabetes dataset.

Functional categories _a

p-value

Functional categories

p-value

MAS5.0:

dChip-PM/MM:

Proteolysis and peptidolysis

0.008

Negative regulation of transcription*

0.024

Ubiquitin-dependent protein catabolism

0.013

Response to stress*

0.024

Modification-dependent protein catabolism

0.015

Phosphagen biosynthesis*_b

0.043

Intracellular protein transport

0.018

Muscle development

0.033

Intracellular signaling cascade*

0.025

Striated muscle contraction

0.043

Lipoprotein biosynthesis*

0.038

dChip-PM:

Protein lipidation

0.039

Fatty acid metabolism*

0.001

Steroid metabolism*

0.047

Organic acid metabolism

0.001

Perception of smell

0.037

RMA:

Sensory perception of chemical stimulus

0.049

Innate immune response

0.016

Acetyl-COA metabolism

0.018

Gutamate signaling pathway

0.034

Inflammatory response

0.040

* Categories known to be directly related to diabetes.

a. Biological process generated by DAVID 2.0 [21] as of Oct. 6, 2005.

b. Genes in the function category are involved in energy metabolism.

Hu and Willsky BMC Bioinformatics 2006 7:12   doi:10.1186/1471-2105-7-12