Table 3

Pathway analysis of 2223 significant genes using a Fisher's Exact Test identified the listed pathways (p < 0.05) that might be related to human liver cancer.

Pathways

The number of significant genes found in a pathway divided by the genes from the chip found in the same pathway

P value

Apoptosis

TGF Beta Induced apoptosis

18/35

0.00055

Cell cycle

P53 signaling pathway

11/21

0.0079

Regulation of P27 during cell cycle progression

6/8

0.0036

Influence of Ras and Rho Protein on G1 to S transition

9/12

0.00031

ECM and Integrin mediated signaling pathway

6/10

0.017

Rb signaling pathway

10/13

0.0001

Cyclin mediated Pathway

13/19

0.000062

G1-S checkpoint

15/21

0.0000072

Growth and differentiation

Insulin signaling pathway

8/16

0.035

TGF beta signaling pathway

7/13

0.021

Amino Acid/Metabolic pathway

Methionine Metabolism

4/5

0.014

Other Signaling pathways

PKC-mediated pathway

8/13

0.0047

Heregulin signaling pathway

14/34

0.027

AR Mediated Signaling Pathway

9/20

0.038

Apigenin Signaling Pathway

6/9

0.0085

Fang et al. BMC Bioinformatics 2005 6(Suppl 2):S6   doi:10.1186/1471-2105-6-S2-S6